COMPOSITION
Each ml contains:
Dexmedetomidine Hydrochloride USP
Eq. to Dexmedetomidine 100mcg
Water for Injection USP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Psycholeptics, other hypnotics and sedatives
ATC code: N05CM18
Dexmedetomidine is a selective alpha-2 receptor agonist with a broad range of pharmacological
properties. It has a sympatholytic effect through decrease of the release of noradrenaline in
sympathetic nerve endings. The sedative effects are mediated through decreased firing of locus
coeruleus, the predominant noradrenergic nucleus, situated in the brainstem. Dexmedetomidine
has analgesic and anaesthetic/analgesic-sparing effects. The cardiovascular effects depend on the
dose; with lower infusion rates the central effects dominate leading to decrease in heart rate and
blood pressure. With higher doses, peripheral vasoconstricting effects prevail leading to an
increase in systemic vascular resistance and blood pressure, while the bradycardic effect is
further emphasised. Dexmedetomidine is relatively free from respiratory depressive effects when
given as monotherapy to healthy subjects.
Sedation of adult ICU (Intensive Care Unit) p
Dexmedetomidine Injection USP 100mcgml