COMPOSITION
\nEach ml contains:
\nFentanyl Citrate USP
\nEq. to Fentanyl 50mcg
\nWater for Injection USP q.s.
\nCLINICAL PHARMACOLOGY
\nPharmacodynamic properties
\nPharmacotherapeutic group: Opioid analgesic
\nATC code: N01AH01
\nFentanyl is a well established chemical entity. It is an opioid analgesic with a high affinity for
\nthe μ-opioid receptor.
\nFentanyl can be used as an analgesic supplement to general anaesthesia or as the sole
\nanaesthetic. Fentanyl preserves cardiac stability, and obtunds stress-related hormonal changes at
\nhigher doses. A dose of 100 micrograms (2.0 ml) is approximately equivalent in analgesic
\nactivity to 10 mg of morphine. The onset of action is rapid. However, the maximum analgesic
\nand respiratory depressant effect may not be noted for several minutes. The usual duration of
\naction of the analgesic effect is approximately 30 minutes after a single IV dose of up to 100
\nmicrograms. Depth of analgesia is dose-related and can be adjusted to the pain level of the
\nsurgical procedure. Fentanyl has a broad safety margin. In rats, the ratio LD50\/ED50 for the
\nlowest level of analgesia is 277, as compared with 69.5 and 4.6 for morphine and pethidine
\nrespectively.
\nLike other opioid analgesics, fentanyl, depending upon the dose and speed of administration, can
\ncause muscle rigidity, as well as euphoria, miosis and bradycardia.
\nHistamine assays and skin-wheal testing in man, as well as in vivo testing in dogs, have
\nindicated that clinically significant histamine release is rare with fentanyl.
\nAll actions of fentanyl are immediately and completely reversed by a specific opioid antagonist,
\nsuch as naloxone.<\/p>\n
COMPOSITION Each ml contains: Fentanyl Citrate USP Eq. to Fentanyl 50mcg Water for Injection USP q.s. CLINICAL PHARMACOLOGY Pharmacodynamic properties Pharmacotherapeutic group: Opioid analgesic ATC code: N01AH01 Fentanyl is a well established chemical entity. It is an opioid analgesic with a high affinity for the \u03bc-opioid receptor. Fentanyl can be used as an analgesic supplement…<\/p>\n","protected":false},"author":1,"featured_media":6351,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5989"}],"collection":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/comments?post=5989"}],"version-history":[{"count":3,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5989\/revisions"}],"predecessor-version":[{"id":6078,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5989\/revisions\/6078"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media\/6351"}],"wp:attachment":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media?parent=5989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/categories?post=5989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/tags?post=5989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}