COMPOSITION
\nEach ml contains:
\nDexmedetomidine Hydrochloride USP
\nEq. to Dexmedetomidine 100mcg
\nWater for Injection USP q.s.
\nCLINICAL PHARMACOLOGY
\nPharmacodynamic properties
\nPharmacotherapeutic group: Psycholeptics, other hypnotics and sedatives
\nATC code: N05CM18
\nDexmedetomidine is a selective alpha-2 receptor agonist with a broad range of pharmacological
\nproperties. It has a sympatholytic effect through decrease of the release of noradrenaline in
\nsympathetic nerve endings. The sedative effects are mediated through decreased firing of locus
\ncoeruleus, the predominant noradrenergic nucleus, situated in the brainstem. Dexmedetomidine
\nhas analgesic and anaesthetic\/analgesic-sparing effects. The cardiovascular effects depend on the
\ndose; with lower infusion rates the central effects dominate leading to decrease in heart rate and
\nblood pressure. With higher doses, peripheral vasoconstricting effects prevail leading to an
\nincrease in systemic vascular resistance and blood pressure, while the bradycardic effect is
\nfurther emphasised. Dexmedetomidine is relatively free from respiratory depressive effects when
\ngiven as monotherapy to healthy subjects.
\nSedation of adult ICU (Intensive Care Unit) p<\/p>\n
COMPOSITION Each ml contains: Dexmedetomidine Hydrochloride USP Eq. to Dexmedetomidine 100mcg Water for Injection USP q.s. CLINICAL PHARMACOLOGY Pharmacodynamic properties Pharmacotherapeutic group: Psycholeptics, other hypnotics and sedatives ATC code: N05CM18 Dexmedetomidine is a selective alpha-2 receptor agonist with a broad range of pharmacological properties. It has a sympatholytic effect through decrease of the release of…<\/p>\n","protected":false},"author":1,"featured_media":6346,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5977"}],"collection":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/comments?post=5977"}],"version-history":[{"count":3,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5977\/revisions"}],"predecessor-version":[{"id":6056,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5977\/revisions\/6056"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media\/6346"}],"wp:attachment":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media?parent=5977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/categories?post=5977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/tags?post=5977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}