COMPOSITION
\nEach ml contains:
\nCisatracurium Besylate USP
\nEq. to Cisatracurium 2mg
\nBenzyl Alcohol USP 0.9%
\n(As preservative in Multi dose Vial)
\nWater for Injection USP q.s.
\nCLINICAL PHARMACOLOGY
\nPharmacodynamic properties
\nPharmacotherapeutic group: Neuromuscular blocking agent
\nATC code: M03AC11
\nCisatracurium is an intermediate-duration, non-depolarising benzylisoquinolinium skeletal
\nmuscle relaxant.
\nClinical studies in man indicated that cisatracurium is not associated with dose dependent
\nhistamine release even at doses up to and including 8 x ED95.
\nMechanism of action
\nCisatracurium binds to cholinergic receptors on the motor end-plate to antagonise the action of
\nacetylcholine, resulting in a competitive block of neuromuscular transmission. This action is
\nreadily reversed by anti-cholinesterase agents such as neostigmine or edrophonium.
\nThe ED95 (dose required to produce 95% depression of the twitch response of the adductor
\npollicis muscle to stimulation of the ulnar nerve) of cisatracurium is estimated to be 0.05 mg\/kg
\nbodyweight during opioid anaesthesia (thiopentone\/fentanyl\/midazolam).
\nThe ED95 of cisatracurium in children during halothane anaesthesia is 0.04 mg\/kg.<\/p>\n
COMPOSITION Each ml contains: Cisatracurium Besylate USP Eq. to Cisatracurium 2mg Benzyl Alcohol USP 0.9% (As preservative in Multi dose Vial) Water for Injection USP q.s. CLINICAL PHARMACOLOGY Pharmacodynamic properties Pharmacotherapeutic group: Neuromuscular blocking agent ATC code: M03AC11 Cisatracurium is an intermediate-duration, non-depolarising benzylisoquinolinium skeletal muscle relaxant. Clinical studies in man indicated that cisatracurium is…<\/p>\n","protected":false},"author":1,"featured_media":6345,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5974"}],"collection":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/comments?post=5974"}],"version-history":[{"count":4,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5974\/revisions"}],"predecessor-version":[{"id":6433,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5974\/revisions\/6433"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media\/6345"}],"wp:attachment":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media?parent=5974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/categories?post=5974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/tags?post=5974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}