{"id":5634,"date":"2021-09-16T10:16:30","date_gmt":"2021-09-16T04:46:30","guid":{"rendered":"http:\/\/induspharma.in\/?p=5634"},"modified":"2022-08-08T19:35:00","modified_gmt":"2022-08-08T14:05:00","slug":"paracetamol-injection","status":"publish","type":"post","link":"https:\/\/induspharma.in\/productslist\/paracetamol-injection\/","title":{"rendered":"Paracetamol Injection"},"content":{"rendered":"

COMPOSITION<\/strong>
\nEach ml contains
\nParacetamol 150 mg
\nBenzyl Alcohol 1.5% v\/v
\nPropylene Glycol 60% v\/v
\nWater for Injection q.s.<\/p>\n

\n

CLINICAL PHARMACOLOGY<\/strong>
\nPharmacodynamic properties<\/strong>
\nPharmacotherapeutic group: Other Analgesics and Antipyretics
\nATC Code: N02BE01<\/p>\n

Paracetamol is a clinically proven analgesic and antipyretic. It produces analgesia by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating centers. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous
\nsystem and to a lesser extent through a peripheral action by blocking pain impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation.
\nParacetamol produces antipyresis by acting centrally on the hypothalamic heat-regulating center to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the
\nhypothalamus.<\/p>\n

Pharmacokinetic properties<\/strong>
\nParacetamol is distributed throughout most body tissues. About 25% of Paracetamol in blood is bound to plasma proteins. The plasma half-life is 1.25 to 3 hours but may be increased by liver damage and following overdose. Paracetamol is metabolized in the liver. About 85% of a dose of Paracetamol is excreted in urine as free and conjugated Paracetamol within 24 hours.<\/p>\n

\n

INDICATION AND USAGE<\/strong>
\nPyrexia of unknown origin, fever and pain, associated with common childhood disorders, tonsilitis, upper respiratory tract infection, postimmunization reactions, post operative fever, after tonsillectomy and other conditions, where patient is unable to take oral medications but where Paracetamol can be administered with advantage for prevention of febrile convulsion, headache, cold, sinusitis, muscle pain, arthritis and toothache. NOTE: Specific therapy with antibiotics or chemotherapeutic drugs of choice should be carried out whenever indicated.<\/p>\n

CONTRA-INDICATION<\/strong>
\nHypersensitivity to Paracetamol. Repeated administration is contraindicated in patients with anemia, cardiac, pulmonary, renal, and hepatic disease.<\/p>\n

DRUG INTERACTIONS<\/strong>
\nParacetamol may enhance the activity of coumarin anticoagulants, but its effect is not generally of clinical significance.<\/p>\n

WARNINGS AND PRECAUTIONS<\/strong>
\nContains sodium sulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life threatening or less severe asthamatic episodes in certain susceptible persons. Also contains Benzyl Alcohol. This should not be administered to new born or premature infants. Paracetamol should be given with care to patients with impaired kidney or liver function.<\/p>\n

SIDE EFFECTS<\/strong>
\nParacetamol has rarely been found to produce any side effects in therapeutic doses and is usually well tolerated by aspirin sensitive patients. Toxicity may result from a single toxic dose of the drug or from chronic ingestion. The following adverse reactions have been reported: skin eruption, haematological toxicity.<\/p>\n

OVERDOSE<\/strong>
\nSymptoms of overdosage may include nausea, vomiting, abdominal pain, diaphoresis, generalized weakness & lethargy. If an overdose of Paracetamol is suspected, blood should be withdrawn immediately for Paracetamol plasma assay, without regard to the presence or absence of symptomatology. The acute hepatotoxicity, nephrotoxicity of paracetamol can be overcome by the administration of sulfinydryl donors, e.g, N-acetyl cysteine which should be given as soon as possible after ingestion. Treatment after 12 hours is not effective. Paracetamol overdose should be treated with gastric lavage if the patient is seen within 24 hours of ingestion of the drug.<\/p>\n

DOSAGE & MODE OF ADMINISTRATION<\/strong>
\nPosology
\nAdults: 2 – 3 ml every 4 to 6 hours.
\nChildren (2 -12 years \/ > 33 kg): Up to 2 ml every 4 to 6 hours.
\nBelow 2 years of age: Half to 1 ml every 4 to 6 hours.
\nRenal impairment
\nIn cases of severe renal impairment, the elimination of paracetamol is slightly delayed, the elimination half-life ranging from 2 to 5.3 hours. For the glucuronide and sulphate conjugates, the elimination rate is 3 times slower in subjects with severe renal impairment than in healthy subjects.Therefore when giving paracetamol to patients with severe renal impairment, the minimum interval between each administration should be increased to at least 6 hours.<\/p>\n

Method of administration
\nThe administration is I.M.\/I.V.<\/p>\n

PREGNANCY AND LACTATION<\/strong>
\nPregnancy
\nClinical experience of the intravenous administration of paracetamol is limited. However, epidemiological data from the use of oral therapeutic doses of paracetamol indicate no undesirable effects in pregnancy or on the health of the foetus \/ newborn infant.
\nProspective data on pregnancies exposed to overdoses did not show an increase in malformation risk.
\nReproductive studies with the intravenous form of paracetamol have not been performed in animals. However, studies with the oral route did not show any malformation of foetotoxic effects.
\nNevertheless, paracetamol should only be used during pregnancy after a careful benefit\/risk assessment. In this case, the recommended dose and duration of treatment must be strictly observed.
\nBreastfeeding
\nAfter oral administration, paracetamol is excreted into breast milk in small quantities. No undesirable effects on nursing infants have been reported.<\/p>\n

Consequently, Paracetamol may be used in breast-feeding women.<\/p>\n

\n

STORAGE CONDITION<\/strong>
\nStore below 30°C, Protected from light, Do not freeze.<\/p>\n

KEEP OUT OF REACH OF CHILDREN<\/strong><\/p>\n

PRESENTATION<\/strong>
\n2ml ampoules packed in cardboard carton along with pack insert.
\nPack of 10 ampoules.<\/p>\n

\nParacetamol Injection 150mgml<\/a>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

COMPOSITION Each ml contains Paracetamol 150 mg Benzyl Alcohol 1.5% v\/v Propylene Glycol 60% v\/v Water for Injection q.s. CLINICAL PHARMACOLOGY Pharmacodynamic properties Pharmacotherapeutic group: Other Analgesics and Antipyretics ATC Code: N02BE01 Paracetamol is a clinically proven analgesic and antipyretic. It produces analgesia by elevation of the pain threshold and antipyresis through action on the…<\/p>\n","protected":false},"author":1,"featured_media":5849,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109],"tags":[122,123],"_links":{"self":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5634"}],"collection":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/comments?post=5634"}],"version-history":[{"count":6,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5634\/revisions"}],"predecessor-version":[{"id":6111,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/posts\/5634\/revisions\/6111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media\/5849"}],"wp:attachment":[{"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/media?parent=5634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/categories?post=5634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/induspharma.in\/productslist\/wp-json\/wp\/v2\/tags?post=5634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}