COMPOSITION
Each ml contains:
Ranitidine Hydrochloride BP 27.9mg
Eq. to Ranitidine 25mg
Phenol (As preservative) BP 0.5% w/v
Water for Injection BP q.s
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: H2 receptor antagonists
ATC Code: A02B A02
Mechanism of action
Ranitidine is specific, rapidly acting histamine H2-antagonist. It inhibits basal and stimulated secretion of gastric acid, reducing both the volume, the acid and pepsin content of the secretion.
The clinical data available mentions the use of ranitidine in children to prevent stress ulcers. No direct evidence for prevention of stress ulcers is available. Treatment for these patients is based on the observation that pH is above 4 after administration of ranitidine. The value of this surrogate parameter in children with stress ulcers remains to be established.
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Ranitidine iNJECTION BP 25mgml