COMPOSITION
Each ml contains
Piroxicam BP 20gm
Benzyl Alcohol BP 2%v/v
(As preservative)
Water for Injection BP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Piroxicam is a non-steroidal anti-inflammatory agent which also possesses analgesic and antipyretic properties. Oedema, erythema, tissue proliferation, fever and pain can all be inhibited in laboratory animals by the administration of piroxicam. It is effective regardless of the aetiology of the inflammation. While its mode of action is not fully understood, independent studies in vitro as well as in vivo have shown that piroxicam interacts at several steps in the immune and inflammation responses through:
Inhibition of prostanoid synthesis, including prostaglandins, through a reversible inhibition of the cyclo-oxygenase enzyme. Inhibition of neutrophil aggregation.
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Piroxicam Injection 20mgml