COMPOSITION
Each ml contains:
Pancuronium Bromide USP 2mg
Water for Injection USP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Muscle relaxants, peripherally acting agents, other quaternary
ammonium compounds
ATC code: M03AC01
Mechanism of action
Pancuronium bromide produces pharmacologic effects similar to those of other non-depolarising
neuromuscular blocking agents. The drug may produce an increase in heart rate which appears to
result from a direct blocking effect on the acetylcholine receptors of the heart. The increase in
heart rate appears to be dose related and is minimal with usual doses. Pancuronium bromide
causes little or no histamine release and no ganglionic blockade and therefore does not cause
hypotension or bronchospasm. Despite its steroidal structure, the drug exhibits no hormonal
activity.
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