Metoclopramide Injection

COMPOSITION
Each ml contains:
Metoclopramide Hydrochloride Monohydrate BP
Eq. to Anhydrous Metoclopramide Hydrochloride 2mg
Water for Injection BP q.s
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Agents stimulating gastro-intestinal motility
ATC Code: A03FA01
Mechanism of action
The action of metoclopramide is closely associated with parasympathetic nervous control of the upper
gastro-intestinal tract, where it has the effect of encouraging normal peristaltic action. This provides for
a fundamental approach to the control of those conditions where disturbed gastro-intestinal motility is a
common underlying factor.
Metoclopramide stimulates activity of the upper gastro-intestinal tract and restores normal co-ordination
and tone. Gastric emptying is accelerated and the resting tone of the gastrooesophageal sphincter is
increased. Metoclopramide is a dopamine-receptor antagonist with a direct anti-emetic effect on the
medullary chemoreceptor trigger zone