COMPOSITION
Each ml contains:
Ferric Hydroxide in Complex with Sucrose
Equivalent to elemental iron 20mg
Water for Injection USP q.s.
Injection is for intravenous use.
When administered by intravenous infusion, the Injection must be diluted with 0.9% Sodium Chloride Injection to a concentration of 1.0 to 2.0 mg/ml of elemental iron.
Osmolarity: Not less than 1150 and not more than
1350m osmol per Lit.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Anti-anaemic preparation, iron, parenteral preparation
ATC code: B03AC
Mechanism of action
Iron sucrose, the active ingredient of Iron Sucrose Injection, is composed of a polynuclear iron(III)-hydroxide core surrounded by a large number of non-covalently bound sucrose molecules. The complex has a weight average molecular weight (Mw) of approximately 43 kDa. The polynuclear iron core has a structure similar to that of the core of the physiological iron storage protein ferritin. The complex is designed to provide, in a controlled manner, utilisable iron for the iron transport and storage proteins in the body (i.e., transferrin and ferritin, respectively).
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Iron Sucrose Injection USP 20mgml