COMPOSITION
Each 2ml contains:
Furosemide BP 20mg
Sodium Hydroxide BP q.s.
Sodium Chloride BP q.s.
Water for Injection BP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Diuretics; Sulfonamides, plain,
ATC Code: C03CA01
Mechanism of action
Furosemide is a potent diuretic. It is an anthranilic acid derivative and chemically it is 4-chloroNfurfuryl-5sulfa-moylanthranilic acid. Furosemide inhibits the reabsorption of sodium and
chloride in the loop of Henle as well as in the proximal and distal tubules; its action is
independent of any inhibitory effect on carbonic anhydrase. The urinary excretion of potassium,
calcium and magnesium is increased by Furosemide. Hyperuricaemia may occur and is
presumed to result from a competitive inhibition of urate secretion in the proximal tubules.
Pharmacodynamic effects
Furosemide has a steep dose-response curve and is designated a high-ceiling diuretic. Following
intravenous administration, the onset of diuresis is within 5 minutes and the duration of diuretic
effect is approximately two hours.
Furosemide Injection BP 20mg