COMPOSITION
Each ml contains:
Dexamethasone Sodium Phosphate
Eq. to Dexamethasone Phosphate 4mg
Methyl Paraben 0.15% W/V
Propyl Paraben 0.02% W/V
Water For Injection q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Glucocorticoids,
ATC Code: H02AB02
Dexamethasone possesses the actions and effects of other basic glucocorticoids and is among the most active members of its class.
Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastro-intestinal tract. They cause profound and varied metabolic effects and in addition, they modify the body’s immune responses to diverse stimuli. Naturally-occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used primarily for their potent anti-inflammatory effects in disorders of many organ systems.
Dexamethasone has predominant glucocorticoid activity with little propensity to promote renal retention of sodium and water. Therefore it does not offer complete replacement therapy and must be supplemented with salt or desoxycorticosterone.
Dexamethasone Sodium Phosphate Injection 4mg ml-converted