Bupivacaine Hydrochloride in Dextrose Injection

COMPOSITION
Each ml contains:
Bupivacaine Hydrochloride USP
Eq. to Anhydrous Bupivacaine Hydrochloride 7.5mg
Dextrose Anhydrous USP 82.5mg
Water for Injection USP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: local anaesthetic
ATC code: N01B B01
Bupivacaine is a long acting local anaesthetic agent of the amide type.
Moderate muscular relaxation of lower extremities.
Motor blockade of the abdominal muscles.
Bupivacaine Hydrochloride in Dextrose Injection is hyperbaric and its initial spread in the
intrathecal space is affected by gravity.
Pharmacokinetic properties
Rapid onset of action and long duration i.e. T10–T12 segments – duration 2–3 hours.
Muscular relaxation of lower extremities lasts 2–2.5 hours.
Blockade of the abdominal muscles lasts 45–60 minutes. The duration of motor blockade does
not exceed duration of analgesia.
In children the pharmacokinetics are similar to that in adults.