Atropine Injection BP
Atropine Injection BP 0.6mg/ml
Atropine Injection BP 1mg/ml
COMPOSITION
Each ml contains:
Atropine Sulfate BP 0.6mg/1mg
Water for Injection BP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Anticholinergic agents.
ATC code: A03BA01.
Mechanism of action
Atropine is an antimuscarinic agent which competitively antagonizes acetylcholine at
postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle,
cardiac muscle and the central nervous system.
Pharmacodynamic effects
Peripheral effects include tachycardia, decreased production of saliva, sweat, bronchial, nasal,
lachrymal and gastric secretions, decreased intestinal motility and inhibition of micturition.
Atropine increases sinus rate and sinoatrial and AV conduction. Usually heart rate is increased
but there may be an initial bradycardia.
Atropine inhibits secretions throughout the respiratory tract and relaxes bronchial smooth muscle
producing bronchodilatation.
Pharmacokinetic properties
Atropine Injection BP