Atracurium Besylate Injection USP 10mg/ml
COMPOSITION
Each ml contains:
Atracurium Besylate USP 10mg
Water for Injection USP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: muscle relaxants, peripherally acting agents; Other quaternary
ammonium components
ATC code: M03AC04
Atracurium besilate 10 mg/ml is a non-depolarising muscle relaxant with medium duration of
action.
The active substance, atracurium besilate, interacts specifically with neurophysiological
processes at the motor end-plate by competitively displacing acetylcholine from its receptor
sites.
As a result of end-plate occupation by atracurium besilate, further depolarisation is inhibited.
Subsequently, skeletal muscles are paralysed since stimulation by motor nerves cannot be
transmitted to the muscles.
Through inhibition of acetylcholine degradation by means of cholinesterase inhibitors, e.g.
neostigmine or edrophonium, an increase of acetylcholine concentration is achieved at all
cholinergic synapses. The balance between atracurium besilate (antagonist) and acetylcholine
(agonist) is shifted in favour of the latter. As a result, stimulation of the muscle can reoccur.
Paediatric population:
The limited data in neonates from literature reports suggest variability in the time to onset and
duration of atracurium in this population as compared to children
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Atracurium Besylate Injection USP 10mgml