COMPOSITION
Each ml contains:
Ascorbic Acid USP 250mg
Water for Injection USP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: ascorbic acid (vitamin C), plain
ATC code: A11GA01
Ascorbic acid, a water-soluble vitamin, is essential for formation of collagen and intercellular material, and therefore necessary for the development of cartilage, bone, teeth and for the healing of wounds. It is also essential for the conversion from folic acid to folinic acid, facilitates iron absorption from the gastro-intestinal tract and influences haemoglobin formation and erythrocyte maturation.
Pharmacokinetic properties
Distribution
widely distributed in body tissues with about 25% bound to plasma proteins. Large amounts are present in leucocytes and platelets. Ascorbic acid crosses the placenta.
Metabolism
readily oxidised to dehydroascorbic acid where some is metabolised to oxalic acid and the inactive ascorbate – 2 – sulphate. Metabolic turnover appears to be greater in females than males.
Excretion
large doses are rapidly excreted in the urine when in excess of the requirements of the body and after an intravenous dose, about 40% is excreted in 8 hours, which is increased to about 70% after tissue saturation. The amount of unchanged drug is dose dependent; in women the excretion of ascorbic acid appears to vary with the stage of the menstrual cycle and it is decreased when taking oral contraceptives.
Ascorbic acid is excreted in breast milk.
Oxalic acid and ascorbate – 2 – sulphate are excreted in the urine.
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Ascorbic Acid Injection USP 250mgml-converted