COMPOSITION
Each ml contains:
Chlorphenamine Maleate BP 10mg
Phenol BP 0.5% w/v
(As preservative in Vials only)
Water for Injection BP q.s.
CLINICAL PHARMACOLOGY
Pharmacodynamic properties
Pharmacotherapeutic group: Antihistamines for systemic use, substituted alkylamines.
ATC code: R06AB04
Antihistamines, including chlorphenamine, used in the treatment of allergy act by competing
with histamine for H1-receptor sites on cells and tissues. Chlorphenamine also has
anticholinergic activity.
The mechanism by which chlorphenamine exerts its anti-emetic, anti- motion sickness and antivertigo effects is not precisely known but may be related to its central actions. Further, most
antihistamines, including chlorphenamine, cross the blood-brain barrier and probably produce
sedation largely by occupying H1-receptors in the brain
Chlorphenamine Injection BP 10mgml