Each ml contains
Netilmicin sulfate USP
Eq. to Netilmicin 25mg/100mg
Benzyl alcohol USP 1% v/v
Water for Injection USP q.s
Pharmacological Classification: Aminoglycoside Antibacterials
ATC Code: J01GB07
Like other aminoglycosides, netilmicin is poorly absorbed after oral administration. Therefore, it
is given parenterally. Following I.M. administration, peak serum concentrations are achieved in
30-40 minutes. After an I.V. “slow bolus”, serum concentrations follow a biphasic curve. The
mean plasma half-life is 2.5 hours after both I.V. and I.M. administration. Tincreases as the dose
increases. It is less in severely burnt, anemic and febrile patients. The volume of distribution is
270 ml/kg (i.e., 20% of body weight). Netilmicin exhibits a low plasma protein binding.
Following parenteral administration, netilmicin is rapidly distributed into tissues and can be
detected in serum, tissue, sputum and pericardial, pleural, synovial and peritoneal fluids.
Netilmicin is excreted via the kidney tubules by glomerular filtration and tubular reabsorption.
About 80% of the dose appears unchanged in urine within 24 hours. The elimination of
netilmicin is reduced in renal disease and in the elderly as renal function declines
Netilmicin Sulfate Injection USP 25mgml & 100mgml