Each ml contains:
Midazolam USP 1mg/5mg
Hydrochloric Acid USP q.s.
Benzyl Alcohol USP 1%v/v
Water for Injection USP q.s.
Pharmacotherapeutic group: Hypnotics and sedatives (benzodiazepine derivatives)
ATC code: N05CD08
Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic
substance with low solubility in water. The basic nitrogen in position 2 of the
imidazobenzodiazepine ring enables the active ingredient in midazolam to form water-soluble
salts with acids. These produce a stable and well tolerated solution for injection or infusion.
The pharmacological effect of midazolam is characterised by short duration because of a rapid
metabolic transformation over a short time. Midazolam has a potent sedative and sleep-inducing
effect. Furthermore, it has the effect of relieving anxiety and convulsions and of relaxing
muscles. After intramuscular or intravenous administration, anterograde amnesia of short
duration occurs; (the patient does not remember events occurring at the time of the substance’s
Midazolam Injection USP 1,5mgml