Each vial contains
Ceftriaxone Sodium USP
Pharmacotherapeutic group: Antibacterials for systemic use, Third-generation cephalosporins.
ATC Code: J01DD04
Mechanism of action
Ceftriaxone inhibits bacterial cell wall synthesis following attachment to penicillin binding
proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which
leads to bacterial cell lysis and death.
Bacterial resistance to ceftriaxone may be due to one or more of the following mechanisms:
• hydrolysis by beta-lactamases, including extended-spectrum beta-lactamases (ESBLs),
carbapenemases and Amp C enzymes that may be induced or stably derepressed in certain
aerobic Gram-negative bacterial species.
• reduced affinity of penicillin-binding proteins for ceftriaxone.
• outer membrane impermeability in Gram-negative organisms.
• bacterial efflux pumps.
Susceptibility testing Breakpoints
Minimum inhibitory concentration (MIC) breakpoints established by the European Committee
on Antimicrobial Susceptibility Testing (EUCAST) are as follows:
Ceftriaxone for Injection USP 1g